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![]() ![]() Most recurrences were metastases to liver and lungs. Nine (12.5%) patients experienced disease recurrence, 8 with tumor regression score=3. Follow-up ranged from 5 months to 12 years. Conversion from laparoscopy to open surgery was higher in the tumor regression score=3 group (21% vs. ![]() Among the other 72 patients, 38 (52.8%) were classified as tumor regression score=3 (no response) and 34 (47.2%) tumor regression score=0-2 (any level of response). 6 patients were later excluded from the long-term follow up since they developed disease progression during neoadjuvant treatment. Results: Initially 78 patients were included. Disease free survival and cancer specific survival rates were documented and matched with the patients’ tumor regression scores. Pathological specimens were ren evaluated and graded (grades 0-3) based on the revised tumor regression scores. neoadjuvant chemoradiotherapy and surgical resection at our medical center. Methods: This retrospective study included rectal cancer patients who received. In this study we evaluated the prevalence and impact of poor-to-no pathological response to neoadjuvant treatment (tumor regression score=3), based on a recently revised grading system on long term oncologic outcomes among rectal cancer patients. Complete pathological response (tumor regression score=0) is associated with excellent prognosis. Purpose: Tumor regression scores are used to evaluate local response to preoperative treatment. Lack of Pathological Response of Rectal Cancer to Neoadjuvant Chemoradiotherapy is Associated with Poorer Long-Term Oncological Outcomes A B S T R A C T ![]()
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